Literature Study Of Pharmacological Effects Of Black Seed (Nigella Sativa) Based On Active Seeds
Keywords:
Jintan Hitam, Efek Farmakologi, TimokuinonAbstract
Jintan Hitam (Nigella sativa) merupakan tanaman rempah yang telah digunakan sebagai obat tradisional. Jintan Hitam (Nigella sativa) diketahui mempunyai banyak efek farmakologis seperti antiinflamasi, analgesik, antipiretik, antimikroba, antihelmentik, antikanker, diuretik, bronkodilator, immunomodulator, hepatoprotektor, renoprotektor, antidiare, antidiabetes, spasmolotik, dan antioksidan. Bagian tanaman yang dimanfaatkan adalah bijinya dengan kandungan utama minyak atsiri yaitu thymoquinone. Penelitian ini bertujuan untuk mengetahui potensi efek farmakologi dari tanaman Jintan Hitam (Nigella sativa) berdasarkan zat aktifnya yaitu thymoquinone. Metode penelitian menggunakan metode studi literatur, dengan pencarian artikel di 3 database yaitu Google Scholar, Science Direct, PubMed, dan menghasilkan 7 artikel ditindaklanjuti. Potensi efek farmakologi Jintan Hitam (Nigella sativa) berdasarkan zat aktif thymoquinone dari minyak atsiri ektrak biji Jintan Hitam (Nigella sativa) yaitu banyak dianalisis sebagai antioksidan, antiinflamasi, immunomodulator, antikanker, dan perlindungan gastro.
References
[1] N. K. Mohammed, M. Y. Abd Manap, C. P. Tan, B. J. Muhialdin, A. M. Alhelli, and A. S. M. Hussin, “The Effects of Different Extraction Methods on Antioxidant Properties, Chemical Composition, and Thermal Behavior of Black Seed (Nigella sativa L.) Oil,” Evidence-based Complement. Altern. Med., vol. 2016, p. 10, 2016, doi: 10.1155/2016/6273817.
[2] A. Ahmad et al., “A review on therapeutic potential of Nigella sativa: A miracle herb,” Asian Pac. J. Trop. Biomed., vol. 3, no. 5, pp. 337–352, 2013, doi: 10.1016/S2221-1691(13)60075-1.
[3] L. Marlinda, “Efektivitas Ekstrak Etanol Biji Jintan Hitam (Nigella sativa Linn.) Terhadap Peningkatan Fagositosis dalam Respon Imun Tubuh,” J. Major., vol. 4, no. 3, pp. 58–64, 2015.
[4] Y. Aldi and Suhatri, “Aktivitas Ekstrak Etanol Biji Jintan Hitam (Nigella sativa Linn.) terhadap Titer Antibodi dan Jumlah Sel Leukosit pada Mencit Putih Jantan,” Sci. J. Farm. dan Kesehat., vol. 1, no. 1, pp. 35–41, 2011, doi: 10.36434/scientia.v1i1.14.
[5] R. Suryadi, M. Ghulamahdi, and A. Kurniawati, “Pemupukan Nitrogen Dan Fosfor Untuk Meningkatkan Pertumbuhan, Produksi Biji Dan Kandungan Thymoquinone Jintan Hitam,” Bul. Penelit. Tanam. Rempah dan Obat, vol. 28, no. 1, pp. 15–28, 2017, doi: 10.21082/bullittro.v28n1.2017.15-28.
[6] M. Amanulloh and E. Krisdayanti, “Jintan Hitam sebagai Imunomodulator dan Anti Inflamasi pada Pasien Asma,” J. Penelit. Perawat Prof., vol. 1, no. 1, pp. 115–120, 2019, doi: 10.37287/jppp.v1i1.32.
[7] S. D. Santoso and I. Suryanto, “KOMPARASI EFEK PEMBERIAN MINYAK JINTAN HITAM (Nigella sativa) DENGAN MINYAK ZAITUN (Olea europea) TERHADAP PENURUNAN GLUKOSA DARAH PADA MENCIT (Mus musculus) STRAIN Balb/c,” J. SainHealth, vol. 1, no. 1, pp. 36–42, 2017, doi: 10.51804/jsh.v1i1.76.36-42.
[8] N. A. Suciyati, N. Nurcahyani, S. Sutyarso, and E. Rosa, “Normality of The Mice’s Fetal Spine during Fennel Flower Extract (Nigella sativa) Feeding,” J. Ilm. Biol. Eksperimen dan Keanekaragaman Hayati, vol. 7, no. 1, pp. 41–47, 2020, doi: 10.23960/jbekh.v7i1.14.
[9] S. H. Suseno, Nurjanah, and T. Faradiba, “Profil Asam Lemak Dan Kestabilan Produk Formulasi Minyak Ikan Dan Habbatussauda,” J. Pengolah. Has. Perikan. Indones., vol. 16, no. 2, pp. 142–149, 2013, doi: 10.17844/jphpi.v16i2.8048.
[10] W. Kooti, Z. Hasanzadeh-Noohi, N. Sharafi-Ahvazi, M. Asadi-Samani, and D. Ashtary-Larky, “Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa),” Chin. J. Nat. Med., vol. 14, no. 10, pp. 732–745, 2016, doi: 10.1016/S1875-5364(16)30088-7.
[11] M. Ramadan, Fawzy, Black Cumin (Nigella sativa) Seeds: Chemistry, Technology, Functionality, and Applications. 2021.
[12] C. Carolin and D. R. Rahadi, “Studi Literatur: Hubungan Dan Pengaruh Motivasi Terhadap Kinerja Karyawan,” Mak. J. Manaj., vol. 6, no. 2, pp. 107–116, 2020, doi: 10.37403/mjm.v6i2.177.
[13] D. Prasetyo, E. P. Santosa, M. Hartono, and M. M. Sirat Pratama, “PENGARUH PEMBERIAN IMUNOMODULATOR JINTAN HITAM (Nigella sativa) TERHADAP TITER ANTIBODI AVIAN INFLUENZA dan NEWCASTLE DISEASE PADA BROILER JANTAN,” J. Ris. dan Inov. Perten., vol. 5, no. 1, pp. 37–42, 2021.
[14] A. R. Hakim and R. Saputri, “Narrative Review: Optimasi Etanol sebagai Pelarut Senyawa Flavonoid dan Fenolik,” J. Surya Med., vol. 6, no. 1, pp. 177–180, 2020, doi: 10.33084/jsm.v6i1.1641.
[15] T. Farkhondeh, S. Samarghandian, A. M. P. Shahri, and F. Samini, “The neuroprotective effects of thymoquinone: A review,” Dose-Response, vol. 16, no. 2, pp. 1–11, 2018, doi: 10.1177/1559325818761455.
[16] R. S. Mardisiwi, A. Kurniawati, E. Sulistyono, and D. D. N. Fardidah, “Pertumbuhan dan Produksi Jintan Hitam pada Beberapa Komposisi Media Tanam dan Interval Penyiraman,” J. Agron. Indones. (Indonesian J. Agron., vol. 46, no. 1, p. 89, 2018, doi: 10.24831/jai.v46i1.16723.
[17] L. W. Peryoga, Retnowati, and B. Siswoyo, “Pengendalian Suhu Kelembaban Ruang Ekstraksi Metode Maserasi Minyak Atsiri Melati Kontroler PID Berbasis Arduino Mega,” J. Mhs. TEUB, vol. 3, no. 1, pp. 1–6, 2015.
[18] H. Nurhasnawati, S. Sukarmi, and F. Handayani, “PERBANDINGAN METODE EKSTRAKSI MASERASI DAN SOKLETASI TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN JAMBU BOL (Syzygium malaccense L.),” J. Ilm. Manuntung, vol. 3, no. 1, pp. 91–95, 2017, doi: 10.51352/jim.v3i1.96.
[19] C. Anam, T. Agustini, and R. Romadhon, “Pengaruh Pelarut Yang Berbeda Pada Ekstraksi Spirulina Platensis Serbuk Sebagai Antioksidan Dengan Metode Soxhletasi,” J. Pengolah. dan Bioteknol. Has. Perikan., vol. 3, no. 4, pp. 106–112, 2014.
[20] A. R. Faoziyah and E. Issusilaningtyas, “Optimalisasi Ektraksi Ikan Sidat Dengan Variasi Metode Ektraksi sebagai Optimization of River Eel Extraction with Variation of Method as the Raw Material for Microcapsule of Coronary Heart Health Supplement,” Pharm. J. Indones., vol. 17, no. 02, pp. 253–263, 2020.
[21] A. Rahma, I. Taufiqurrahman, and Edyson, “PERBEDAAN TOTAL FLAVONOID ANTARA METODE MASERASI DENGAN SOKLETASI PADA EKSTRAK DAUN RAMANIA (Bouea macrophylla Griff),” Dentino J. Kedokt. gigi, vol. 1, no. 1, pp. 22–27, 2017.
[22] S. W. Ritonga, “UJI BEBERAPA KOMODITAS PADA ALAT PENGEPRES MINYAK SEMI MEKANIS,” pp. 1–72, 2016.
[23] I. L. Utami, “PEMBUATAN ETANOL DARI BUAH MENGKUDU,” J. Tek. Kim., vol. 4, no. 1, pp. 255–159, 2009.
[24] A. Sahid, D. Pandiangan, P. Siahaan, and M. J. Rumondor, “Uji Sitotoksisitas Ekstrak Metanol Daun Sisik Naga (Drymoglossum piloselloides Presl.) terhadap Sel Leukemia P388,” J. MIPA, vol. 2, no. 2, pp. 94–99, 2013, doi: 10.35799/jm.2.2.2013.2758.
[25] M. Abdillah, N. R. K. Nazilah, and E. Agustina, “IDENTIFIKASI SENYAWA AKTIF DALAM EKSTRAK METANOL DAGING BUAH KURMA JENIS AJWA ( Phoenix dactylvera L .) Dosen / Program Studi Biologi UIN Sunan Ampel Abdillah et al , Identifikasi Senyawa Aktif Abdillah et al , Identifikasi Senyawa Aktif,” no. 3, pp. 69–74, 2017.
[26] F. A. R. Sambada and A. Prasetyadi, “Karakteristik Petroleum Eter Dan Dietil Eter Sebagai Fluida Kerja Pompa Air Energi Termal,” J. Penelit. Saintek, vol. 19, no. 1, pp. 9–22, 2014.
[27] S. Iswari and Y. A. Pujiastuti, “Pengaruh Suhu Dan Waktu Operasi Pada Proses Destilasi Untuk the Effect of Temperature and Operation Time on the Process of Distilation for Aquades Processing in Faculty of Engineering University Mulawarman,” J. Chemurg., vol. 01, no. 1, pp. 31–35, 2017.
[28] S. A. Khan, A. M. Khan, S. Karim, M. Amjad, G. A. Damanhouri, and Z. Mirza, “Panacea seed ‘“ Nigella ”’: A review focusing on regenerative effects for gastric ailments,” Saudi J. Biol. Sci., vol. 23, no. 4, pp. 542–553, 2016, doi: 10.1016/j.sjbs.2014.10.001.
[29] M. Magdy, E. Hanan, and E. Nabila, “Thymoquinone : Novel gastroprotective mechanisms,” Eur. J. Pharmacol., vol. 697, no. 1–3, pp. 126–131, 2012, doi: 10.1016/j.ejphar.2012.09.042.
[30] O. M. S. Al-shaha and S. A. Mohammed, “Gastro protective effect of oil extract of Nigella sativa Seeds against Aspirin-Induced Gastric Ulcer in Albino Rats,” J. Entomol. Zool. Stud., vol. 5, no. 4, pp. 725–732, 2017.
[31] N. Ozdemir, M. Nur, K. T. Tat, and A. Tekin, “Effect of black cumin oil on the oxidative stability and sensory characteristics of mayonnaise,” J. Food Sci. Technol., vol. 55, no. 4, pp. 1562–1568, 2018, doi: 10.1007/s13197-018-3075-4.
[32] L. Bordoni et al., “Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes,” vol. 8, no. 51, pp. 1–12, 2019, doi: 10.3390/antiox8020051.
[33] A. F. C. Silva, P. I. Haris, M. L. Serralheiro, and R. Pacheco, “Mechanism of action and the biological activities of Nigella sativa oil components,” Food Biosci., vol. 38, no. February, pp. 1–11, 2020, doi: 10.1016/j.fbio.2020.100783.
[34] S. H. Reddy, A. S. Al-kalbani, and A. S. Al-rawahi, “STUDIES ON PHYTOCHEMICAL SCREENING-GC-MS CHARACTERIZATION , ANTIMICROBIAL AND ANTIOXIDANT ASSAY OF BLACK CUMIN SEEDS ( NIGELLA SATIVA ) AND SENNA ALEXANDRIA ( CASSIA ANGUSTIFOLIA ) SOLV ... ANTIMICROBIAL AND ANTIOXIDANT ASSAY OF BLACK CUMIN SEEDS ( NIGELL,” vol. 9, no. 2, pp. 490–497, 2018, doi: 10.13040/IJPSR.0975-8232.9(2).490-97.
[35] R. Schneider-stock, I. H. Fakhoury, A. M. Zaki, C. O. El-baba, and H. U. Gali-muhtasib, “Thymoquinone : fifty years of success in the battle against cancer models,” Drug Discov. Today, vol. 19, no. 1, pp. 18–30, 2014, doi: 10.1016/j.drudis.2013.08.021.
[36] M. Ns, R. Be, H. Javeed, D. Ganavi, and S. Jk, “Evaluation of Nigella sativa ( Black cumin ) for anti- cancer and anti-inflammatory activities,” Int. J. Herb. Med., vol. 8, no. 5, pp. 1–9, 2020.
[37] S. Nikakhlagh et al., “Herbal treatment of allergic rhinitis : the use of Nigella sativa ?,” Am. J. Otolaryngol. Neck Med. Surg., vol. 32, no. 5, pp. 402–407, 2011, doi: 10.1016/j.amjoto.2010.07.019.
[38] R. Muthia and K. I. Astuti, “Efek Imunomodulator Infusa Umbi Bawang Dayak (Eleutherina palmifolia L. Merr) Dengan Metode Bersihan Karbon,” J. Pharmascience, vol. 5, no. 1, pp. 63–70, 2018, doi: 10.20527/jps.v5i1.5787.
[39] A. E. Koshak, N. M. Yousif, B. L. Fiebich, and E. A. Koshak, “Comparative Immunomodulatory Activity of Nigella sativa L . Preparations on Proinflammatory Mediators : A Focus on Asthma,” vol. 9, no. October, pp. 1–11, 2018, doi: 10.3389/fphar.2018.01075.
[40] H. A. Bakathir and N. A. Abbas, “Detection of Antibacterial Effect of Nigella sativa Ground Seeds with Water,” vol. 8, no. 2, pp. 159–164, 2011.
[41] T. Monika, P. Sasikala, and M. V. B. Reddy, “A INVESTIGATIONAL STUDY OF ANTIBACTERIAL ACTIVITIES OF NIGELLA SATIVA ON MASTITS IN DAIRY CROSSBRED COWS,” Int. J. Adv. Sci. Tech. Res., vol. 4, no. 3, pp. 273–283, 2013.
[2] A. Ahmad et al., “A review on therapeutic potential of Nigella sativa: A miracle herb,” Asian Pac. J. Trop. Biomed., vol. 3, no. 5, pp. 337–352, 2013, doi: 10.1016/S2221-1691(13)60075-1.
[3] L. Marlinda, “Efektivitas Ekstrak Etanol Biji Jintan Hitam (Nigella sativa Linn.) Terhadap Peningkatan Fagositosis dalam Respon Imun Tubuh,” J. Major., vol. 4, no. 3, pp. 58–64, 2015.
[4] Y. Aldi and Suhatri, “Aktivitas Ekstrak Etanol Biji Jintan Hitam (Nigella sativa Linn.) terhadap Titer Antibodi dan Jumlah Sel Leukosit pada Mencit Putih Jantan,” Sci. J. Farm. dan Kesehat., vol. 1, no. 1, pp. 35–41, 2011, doi: 10.36434/scientia.v1i1.14.
[5] R. Suryadi, M. Ghulamahdi, and A. Kurniawati, “Pemupukan Nitrogen Dan Fosfor Untuk Meningkatkan Pertumbuhan, Produksi Biji Dan Kandungan Thymoquinone Jintan Hitam,” Bul. Penelit. Tanam. Rempah dan Obat, vol. 28, no. 1, pp. 15–28, 2017, doi: 10.21082/bullittro.v28n1.2017.15-28.
[6] M. Amanulloh and E. Krisdayanti, “Jintan Hitam sebagai Imunomodulator dan Anti Inflamasi pada Pasien Asma,” J. Penelit. Perawat Prof., vol. 1, no. 1, pp. 115–120, 2019, doi: 10.37287/jppp.v1i1.32.
[7] S. D. Santoso and I. Suryanto, “KOMPARASI EFEK PEMBERIAN MINYAK JINTAN HITAM (Nigella sativa) DENGAN MINYAK ZAITUN (Olea europea) TERHADAP PENURUNAN GLUKOSA DARAH PADA MENCIT (Mus musculus) STRAIN Balb/c,” J. SainHealth, vol. 1, no. 1, pp. 36–42, 2017, doi: 10.51804/jsh.v1i1.76.36-42.
[8] N. A. Suciyati, N. Nurcahyani, S. Sutyarso, and E. Rosa, “Normality of The Mice’s Fetal Spine during Fennel Flower Extract (Nigella sativa) Feeding,” J. Ilm. Biol. Eksperimen dan Keanekaragaman Hayati, vol. 7, no. 1, pp. 41–47, 2020, doi: 10.23960/jbekh.v7i1.14.
[9] S. H. Suseno, Nurjanah, and T. Faradiba, “Profil Asam Lemak Dan Kestabilan Produk Formulasi Minyak Ikan Dan Habbatussauda,” J. Pengolah. Has. Perikan. Indones., vol. 16, no. 2, pp. 142–149, 2013, doi: 10.17844/jphpi.v16i2.8048.
[10] W. Kooti, Z. Hasanzadeh-Noohi, N. Sharafi-Ahvazi, M. Asadi-Samani, and D. Ashtary-Larky, “Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa),” Chin. J. Nat. Med., vol. 14, no. 10, pp. 732–745, 2016, doi: 10.1016/S1875-5364(16)30088-7.
[11] M. Ramadan, Fawzy, Black Cumin (Nigella sativa) Seeds: Chemistry, Technology, Functionality, and Applications. 2021.
[12] C. Carolin and D. R. Rahadi, “Studi Literatur: Hubungan Dan Pengaruh Motivasi Terhadap Kinerja Karyawan,” Mak. J. Manaj., vol. 6, no. 2, pp. 107–116, 2020, doi: 10.37403/mjm.v6i2.177.
[13] D. Prasetyo, E. P. Santosa, M. Hartono, and M. M. Sirat Pratama, “PENGARUH PEMBERIAN IMUNOMODULATOR JINTAN HITAM (Nigella sativa) TERHADAP TITER ANTIBODI AVIAN INFLUENZA dan NEWCASTLE DISEASE PADA BROILER JANTAN,” J. Ris. dan Inov. Perten., vol. 5, no. 1, pp. 37–42, 2021.
[14] A. R. Hakim and R. Saputri, “Narrative Review: Optimasi Etanol sebagai Pelarut Senyawa Flavonoid dan Fenolik,” J. Surya Med., vol. 6, no. 1, pp. 177–180, 2020, doi: 10.33084/jsm.v6i1.1641.
[15] T. Farkhondeh, S. Samarghandian, A. M. P. Shahri, and F. Samini, “The neuroprotective effects of thymoquinone: A review,” Dose-Response, vol. 16, no. 2, pp. 1–11, 2018, doi: 10.1177/1559325818761455.
[16] R. S. Mardisiwi, A. Kurniawati, E. Sulistyono, and D. D. N. Fardidah, “Pertumbuhan dan Produksi Jintan Hitam pada Beberapa Komposisi Media Tanam dan Interval Penyiraman,” J. Agron. Indones. (Indonesian J. Agron., vol. 46, no. 1, p. 89, 2018, doi: 10.24831/jai.v46i1.16723.
[17] L. W. Peryoga, Retnowati, and B. Siswoyo, “Pengendalian Suhu Kelembaban Ruang Ekstraksi Metode Maserasi Minyak Atsiri Melati Kontroler PID Berbasis Arduino Mega,” J. Mhs. TEUB, vol. 3, no. 1, pp. 1–6, 2015.
[18] H. Nurhasnawati, S. Sukarmi, and F. Handayani, “PERBANDINGAN METODE EKSTRAKSI MASERASI DAN SOKLETASI TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN JAMBU BOL (Syzygium malaccense L.),” J. Ilm. Manuntung, vol. 3, no. 1, pp. 91–95, 2017, doi: 10.51352/jim.v3i1.96.
[19] C. Anam, T. Agustini, and R. Romadhon, “Pengaruh Pelarut Yang Berbeda Pada Ekstraksi Spirulina Platensis Serbuk Sebagai Antioksidan Dengan Metode Soxhletasi,” J. Pengolah. dan Bioteknol. Has. Perikan., vol. 3, no. 4, pp. 106–112, 2014.
[20] A. R. Faoziyah and E. Issusilaningtyas, “Optimalisasi Ektraksi Ikan Sidat Dengan Variasi Metode Ektraksi sebagai Optimization of River Eel Extraction with Variation of Method as the Raw Material for Microcapsule of Coronary Heart Health Supplement,” Pharm. J. Indones., vol. 17, no. 02, pp. 253–263, 2020.
[21] A. Rahma, I. Taufiqurrahman, and Edyson, “PERBEDAAN TOTAL FLAVONOID ANTARA METODE MASERASI DENGAN SOKLETASI PADA EKSTRAK DAUN RAMANIA (Bouea macrophylla Griff),” Dentino J. Kedokt. gigi, vol. 1, no. 1, pp. 22–27, 2017.
[22] S. W. Ritonga, “UJI BEBERAPA KOMODITAS PADA ALAT PENGEPRES MINYAK SEMI MEKANIS,” pp. 1–72, 2016.
[23] I. L. Utami, “PEMBUATAN ETANOL DARI BUAH MENGKUDU,” J. Tek. Kim., vol. 4, no. 1, pp. 255–159, 2009.
[24] A. Sahid, D. Pandiangan, P. Siahaan, and M. J. Rumondor, “Uji Sitotoksisitas Ekstrak Metanol Daun Sisik Naga (Drymoglossum piloselloides Presl.) terhadap Sel Leukemia P388,” J. MIPA, vol. 2, no. 2, pp. 94–99, 2013, doi: 10.35799/jm.2.2.2013.2758.
[25] M. Abdillah, N. R. K. Nazilah, and E. Agustina, “IDENTIFIKASI SENYAWA AKTIF DALAM EKSTRAK METANOL DAGING BUAH KURMA JENIS AJWA ( Phoenix dactylvera L .) Dosen / Program Studi Biologi UIN Sunan Ampel Abdillah et al , Identifikasi Senyawa Aktif Abdillah et al , Identifikasi Senyawa Aktif,” no. 3, pp. 69–74, 2017.
[26] F. A. R. Sambada and A. Prasetyadi, “Karakteristik Petroleum Eter Dan Dietil Eter Sebagai Fluida Kerja Pompa Air Energi Termal,” J. Penelit. Saintek, vol. 19, no. 1, pp. 9–22, 2014.
[27] S. Iswari and Y. A. Pujiastuti, “Pengaruh Suhu Dan Waktu Operasi Pada Proses Destilasi Untuk the Effect of Temperature and Operation Time on the Process of Distilation for Aquades Processing in Faculty of Engineering University Mulawarman,” J. Chemurg., vol. 01, no. 1, pp. 31–35, 2017.
[28] S. A. Khan, A. M. Khan, S. Karim, M. Amjad, G. A. Damanhouri, and Z. Mirza, “Panacea seed ‘“ Nigella ”’: A review focusing on regenerative effects for gastric ailments,” Saudi J. Biol. Sci., vol. 23, no. 4, pp. 542–553, 2016, doi: 10.1016/j.sjbs.2014.10.001.
[29] M. Magdy, E. Hanan, and E. Nabila, “Thymoquinone : Novel gastroprotective mechanisms,” Eur. J. Pharmacol., vol. 697, no. 1–3, pp. 126–131, 2012, doi: 10.1016/j.ejphar.2012.09.042.
[30] O. M. S. Al-shaha and S. A. Mohammed, “Gastro protective effect of oil extract of Nigella sativa Seeds against Aspirin-Induced Gastric Ulcer in Albino Rats,” J. Entomol. Zool. Stud., vol. 5, no. 4, pp. 725–732, 2017.
[31] N. Ozdemir, M. Nur, K. T. Tat, and A. Tekin, “Effect of black cumin oil on the oxidative stability and sensory characteristics of mayonnaise,” J. Food Sci. Technol., vol. 55, no. 4, pp. 1562–1568, 2018, doi: 10.1007/s13197-018-3075-4.
[32] L. Bordoni et al., “Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes,” vol. 8, no. 51, pp. 1–12, 2019, doi: 10.3390/antiox8020051.
[33] A. F. C. Silva, P. I. Haris, M. L. Serralheiro, and R. Pacheco, “Mechanism of action and the biological activities of Nigella sativa oil components,” Food Biosci., vol. 38, no. February, pp. 1–11, 2020, doi: 10.1016/j.fbio.2020.100783.
[34] S. H. Reddy, A. S. Al-kalbani, and A. S. Al-rawahi, “STUDIES ON PHYTOCHEMICAL SCREENING-GC-MS CHARACTERIZATION , ANTIMICROBIAL AND ANTIOXIDANT ASSAY OF BLACK CUMIN SEEDS ( NIGELLA SATIVA ) AND SENNA ALEXANDRIA ( CASSIA ANGUSTIFOLIA ) SOLV ... ANTIMICROBIAL AND ANTIOXIDANT ASSAY OF BLACK CUMIN SEEDS ( NIGELL,” vol. 9, no. 2, pp. 490–497, 2018, doi: 10.13040/IJPSR.0975-8232.9(2).490-97.
[35] R. Schneider-stock, I. H. Fakhoury, A. M. Zaki, C. O. El-baba, and H. U. Gali-muhtasib, “Thymoquinone : fifty years of success in the battle against cancer models,” Drug Discov. Today, vol. 19, no. 1, pp. 18–30, 2014, doi: 10.1016/j.drudis.2013.08.021.
[36] M. Ns, R. Be, H. Javeed, D. Ganavi, and S. Jk, “Evaluation of Nigella sativa ( Black cumin ) for anti- cancer and anti-inflammatory activities,” Int. J. Herb. Med., vol. 8, no. 5, pp. 1–9, 2020.
[37] S. Nikakhlagh et al., “Herbal treatment of allergic rhinitis : the use of Nigella sativa ?,” Am. J. Otolaryngol. Neck Med. Surg., vol. 32, no. 5, pp. 402–407, 2011, doi: 10.1016/j.amjoto.2010.07.019.
[38] R. Muthia and K. I. Astuti, “Efek Imunomodulator Infusa Umbi Bawang Dayak (Eleutherina palmifolia L. Merr) Dengan Metode Bersihan Karbon,” J. Pharmascience, vol. 5, no. 1, pp. 63–70, 2018, doi: 10.20527/jps.v5i1.5787.
[39] A. E. Koshak, N. M. Yousif, B. L. Fiebich, and E. A. Koshak, “Comparative Immunomodulatory Activity of Nigella sativa L . Preparations on Proinflammatory Mediators : A Focus on Asthma,” vol. 9, no. October, pp. 1–11, 2018, doi: 10.3389/fphar.2018.01075.
[40] H. A. Bakathir and N. A. Abbas, “Detection of Antibacterial Effect of Nigella sativa Ground Seeds with Water,” vol. 8, no. 2, pp. 159–164, 2011.
[41] T. Monika, P. Sasikala, and M. V. B. Reddy, “A INVESTIGATIONAL STUDY OF ANTIBACTERIAL ACTIVITIES OF NIGELLA SATIVA ON MASTITS IN DAIRY CROSSBRED COWS,” Int. J. Adv. Sci. Tech. Res., vol. 4, no. 3, pp. 273–283, 2013.
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2021-12-08
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Nurchollifah, Y., Wijayatri, R., & Hidayat, I. W. (2021). Literature Study Of Pharmacological Effects Of Black Seed (Nigella Sativa) Based On Active Seeds. Prosiding University Research Colloquium, 815–832. Retrieved from https://repository.urecol.org/index.php/proceeding/article/view/1647
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Copyright (c) 2021 Yeny Nurchollifah, Ratna Wijayatri, Imron Wahyu Hidayat
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
