The Effectiveness of Typhonium Flagelliforme for Breast Cancer: A Narrative Review
Keywords:
Typhonium flagelliforme, antikanker, kanker payudara, MCF-7, T47D, MDA-MB-231Abstract
Kanker payudara merupakan salah satu kanker yang paling sering terjadi pada wanita dan penyumbang angka kematian terbanyak akibat kanker. Global Cancer Observation (GLOBOCAN) tahun 2018 menyatakan bahwa kanker payudara merupakan kasus kanker yang paling banyak terjadi di Indonesia, yakni sebanyak 58.256 kasus atau 16,7% dari total 348.809 kasus kanker. Salah satu tanaman yang dapat mengatasi permasalahan kanker payudara yaitu tanaman keladi tikus (Typhonium flagelliforme). Tanaman keladi tikus memiliki aktivitas antikanker. Tujuan dari tinjauan ini adalah untuk mengetahui aktivitas antikanker tanaman keladi tikus sebagai agen antikanker payudara. Penelitian ini menggunakan metode studi literatur dengan 8 artikel penelitian mengenai tanaman keladi tikus sebagai antikanker payudara dalam kurun waktu 10 tahun terakhir. Hasil penelitian ini menunjukan bahwa ekstrak tanaman keladi tikus (Typhonium flagelliforme) memiliki aktivitas terhadap sel kanker payudara dengan kategori sitotoksik potensial yang dapat digunakan sebagai agen antikanker karena memiliki nilai IC50<100?g/ml. Ekstrak tanaman keladi tikus (Typhonium flagelliforme) dengan pelarut etanol memiliki aktivitas yang paling kuat terhadap sel kanker payudara. Kandungan senyawa pada tanaman keladi tikus diantaranya senyawa fitoestrogen, alkaloid, flavonoid, saponin, terpenoid, steroid, glikosida, asam linoleate, asam oktadekanoat, asam heksadekanoat dan RIP (Ribosome Inacting Protein), keseluruhan senyawa tersebut memiliki aktivitas antikanker.
References
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[20] A. Putra, Tjahyono, and Winarto, “Efektivitas Ekstrak Umbi Typhonium flagelliforme Fraksi Diklorometanolik dalam Menghambat Proliferasi Sel MCF-7 Kanker Payudara,” J. Indones. Med. Assoc., vol. 62, no. 1, pp. 5–10, 2012.
[21] Z. S. Kusumawati, A. Syarifuddin, I. W. Hidayat, and R. Wijayatri, “PENAPISAN FRAKSI TERAKTIF BIJI PEPAYA TERHADAP BAKTERI Staphylococcus aureus DAN UJI KLT BIOAUTOGRAFI,” Borobudur Pharm. Rev., vol. 1, no. 1, pp. 1–11, 2021.
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[24] A. Fatima and H. F. Yee, “In silico screening of mutated K-ras inhibitors from malaysian Typhonium flagelliforme for non-small cell lung cancer,” Adv. Bioinformatics, vol. 2014, no. July, 2014, doi: 10.1155/2014/431696.
[25] Chodidjah, T. Nasihun, E. Widayati, and E. Goenarwo, “Typhonium flagelliforme decreases protein expression in murine breast cancer,” Universa Med., vol. 33, no. 3, pp. 163–170, 2014.
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[28] E. Katrin, H. Winarno, Susanto, and F. N., “Karakteristika dan Khasiat Daun Keladi Tikus ( Typhonium divaricatum ( L .) Decne ) Iradiasi,” J. Ilm. Apl. Isot. dan Radiasi, vol. 8, no. 1, pp. 31–35, 2012, [Online]. Available: http://jurnal.batan.go.id/index.php/jair/article/view/492.
[29] N. M. Putram, I. Setyaningsih, K. Tarman, and M. Nursid, “Anticancer Activity from Active Fraction of Sea Cucumber,” vol. 20, pp. 53–62, 2017.
[30] A. Putra, Tjahjono, and Winarto, “Ekstrak Keladi Tikus (Typhonium flagelliforme) Fraksi Diklorometanolik dan Ekspresi Caspase-3 dan p21 Cell-Line Kanker Payudara MCF-7,” Media Med. Indones., vol. 46, no. 14, pp. 6–11, 2012.
[31] C. Li et al., “Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate,” Carcinogenesis, vol. 32, no. 8, pp. 1251–1258, 2011, doi: 10.1093/carcin/bgr092.
[32] E.-S. Abdel-Hameed, S. Bazaid, M. Shohayeb, M. El-Sayed, and E. Eman, “Phytochemical Studies and Evaluation of Antioxidant, Anticancer and Antimicrobial Properties of Conocarpus erectus L. Growing in Taif, Saudi Arabia,” European J. Med. Plants, vol. 2, no. 2, pp. 93–112, 2012, doi: 10.9734/ejmp/2012/1040.
[2] S. Rahayu, F. S. Nugraha, and M. J. Shidiq, “Analisis Tingkat Keberhasilan Cryoterapy Menggunakan Neural Network,” J. Pilar Nusa Mandiri, vol. 15, no. 2, pp. 141–148, 2019, doi: 10.33480/pilar.v15i2.599.
[3] A. P. Mazna, Y. Riastiti, and A. Iskandar, “Hubungan Tingkat Pengetahun Kanker Dengan Tingkat Kepatuhan Radioterapi Pada Pasien Kanker Di Instalasi Radioterapi RSUD Abdul Wahab Sjahranie Samarinda,” Med. Heal. Sci. J., vol. 4, no. 1, pp. 1–5, 2020.
[4] N. A. Khiru Nasir and S. P. Mohd Bohari, “Cytotoxicity Effects of Typhonium Flagelliforme and Clinacanthus Nutans on Breast Cancer Cells,” J. Teknol., vol. 77, no. 31, pp. 45–50, 2015, doi: 10.11113/jt.v77.6902.
[5] Syafruddin, Suriani, Nahdawati, and S. R. Pakadang, “Pengaruh Ekstrak Daun Keladi Tikus (Typhonium flagelliforme) Terhadap Aktivitas Antimutagenik Pada Mencit (Mus musculus) dengan Menggunakan Metode Mikronukleus Assay,” Media Farm., vol. 14, no. 1, pp. 35–44, 2018, doi: 10.1017/CBO9781107415324.004.
[6] R. M. Zafrial and R. Amalia, “Artikel Tinjauan : Anti Kanker dari Tanaman Herbal,” J. Ilm. Farm. Indones., vol. 16, no. 1, pp. 15–23, 2018, [Online]. Available: http://jurnal.unpad.ac.id/farmaka/article/viewFile/17332/pdf.
[7] E. Purwaningsih, E. Widayanti, and Y. Suciati, “Cytotoxicity assay of Typhonium flagelliforme Lodd against breast and cervical cancer cells,” Universa Med., vol. 33, no. 2, pp. 75–82, 2014, [Online]. Available: https://univmed.org/ejurnal/index.php/medicina/article/download/7/6.
[8] D. B. Pambudi, N. N. Fajriyah, and R. A. Maharisti, “Test of ?-Amylase Inhibition Activity in Ethanol Extract of Fennel Leaves (Foeniculum vulgare Mill.) Using Elisa Reader,” Urecol Journal. Part C Heal. Sci., vol. 1, no. 1, pp. 1–6, 2021.
[9] M. Singh, D. Kumar, S. Deepak, and G. Singh, “Typhonium Flagelliforme : a multipurpose plant,” Int. Res. J. Pharm., vol. 4, no. June 2014, pp. 45–48, 2013, doi: 10.7897/2230-8407.04308.
[10] A. Nurrochmad, E. Lukitaningsih, and E. Meiyanto, “Anti Cancer Activity of Rodent Tuber (Thyphonium flagelliforme (lodd.) Blume on Human Breast Cancer t47d Cells,” Int. J. Phytomedicine, vol. 3, pp. 138–146, 2011, [Online]. Available: http://ccrc.farmasi.ugm.ac.id/wp-content/uploads/63889703.pdf.
[11] E. Purwaningsih, E. Widayanti, and Y. Suciati, “Cytotoxicity assay of Typhonium flagelliforme Lodd Against Breast and Cervical Cancer Cells,” Universa Med., vol. 33, no. 2, pp. 75–82, 2014.
[12] E. Purwaningsih, T. Susmiarsih, and I. Kusuma, “Cytotoxicity of Pheophorbide and Andrographolide Combination on MCF-7 Cancer Cell Culture,” J. Herbs, Spices Med. Plants, vol. 26, no. 2, pp. 148–154, 2020, doi: 10.1080/10496475.2019.1688747.
[13] M. Alfarabi, S. Rosmalawati, M. Bintang, Miftahudin, E. Rofa’ani, and Chaidir, “Antiproliferation Activity of Tuber Protein from Typhonium Flagelliforme (Lodd.) Blume on MCF-7 Cell Line,” Int. J. Biosci., vol. 6, no. 12, pp. 52–60, 2015, doi: 10.12692/ijb/6.12.52-60.
[14] A. Putra, I. Riwanto, S. Putra, and I. Wijaya, “Typhonium Flagelliforme Extract Induce Apoptosis in Breast Cancer Stem Cells by Suppressing Survivin,” J. Cancer Res. Ther., vol. 14, no. 7, pp. 1525–1534, 2020, doi: 10.4103/jcrt.JCRT.
[15] N. F. Sianipar, K. Assidqi, R. Purnamaningsih, and T. Herlina, “In Vitro Cytotoxic Activity of Rodent Tuber Mutant Plant (Typhonium Flagelliforme Lodd.) Against To Mcf-7 Breast Cancer Cell Line,” Asian J. Pharm. Clin. Res., vol. 12, no. 3, pp. 185–189, 2019, doi: 10.22159/ajpcr.2019.v12i3.29651.
[16] Y. Farida, W. P. Suwarso, and W. Sumaryono, “Biological Activity Test of Extracts and Fractions There of Keladi Tikus Leaves (Typhonium flagelliforme Lodd) Blume,” Proc. 2nd Int. Symp. Temulawak 40th Natl. Semin. Indones. Med. Plants, vol. May, no. 26–27, p. Bogor-Indonesia, 2011.
[17] T. Rahayu, S. Syafril, I. S. Wekke, and R. Erlinda, “Teknik Menulis Review Literatur Dalam Sebuah Artikel Ilmiah,” no. September, pp. 1–16, 2019, doi: 10.31227/osf.io/z6m2y.
[18] E. Purwaningsih, Y. Suciati, and E. Widayanti, “Anticancer Effect of a Typhonium flagelliforme L. in Raji Cells Through Telomerase Expression,” Indones. J. Cancer Chemoprevention, vol. 8, no. 1, p. 15, 2017, doi: 10.14499/indonesianjcanchemoprev8iss1pp15-20.
[19] L. Widowati and H. Mudahar, “Ujiaktivitas ekstrak etanol 50% umbi keladi tikus (typhoniumflagelliforme (lood) bi) terhadap sel kanker payudara mcf-7 in vitro,” vol. XIX, pp. 3–8, 2009.
[20] A. Putra, Tjahyono, and Winarto, “Efektivitas Ekstrak Umbi Typhonium flagelliforme Fraksi Diklorometanolik dalam Menghambat Proliferasi Sel MCF-7 Kanker Payudara,” J. Indones. Med. Assoc., vol. 62, no. 1, pp. 5–10, 2012.
[21] Z. S. Kusumawati, A. Syarifuddin, I. W. Hidayat, and R. Wijayatri, “PENAPISAN FRAKSI TERAKTIF BIJI PEPAYA TERHADAP BAKTERI Staphylococcus aureus DAN UJI KLT BIOAUTOGRAFI,” Borobudur Pharm. Rev., vol. 1, no. 1, pp. 1–11, 2021.
[22] I. Tusanti, A. Johan, and R. Kisdjamiatun, “Sitotoksisitas in vitro ekstrak etanolik buah parijoto (Medinilla speciosa, reinw.ex bl.) terhadap sel kanker payudara T47D,” J. Gizi Indones. (The Indones. J. Nutr., vol. 2, no. 2, pp. 53–58, 2014, doi: 10.14710/jgi.2.2.53-58.
[23] A. Arab, S. Akbarian, R. Ghiyasvand, and M. Miraghajani, “The effects of conjugated linoleic acids on breast cancer: A systematic review,” Adv. Biomed. Res., vol. 5, no. 1, p. 115, 2016, doi: 10.4103/2277-9175.185573.
[24] A. Fatima and H. F. Yee, “In silico screening of mutated K-ras inhibitors from malaysian Typhonium flagelliforme for non-small cell lung cancer,” Adv. Bioinformatics, vol. 2014, no. July, 2014, doi: 10.1155/2014/431696.
[25] Chodidjah, T. Nasihun, E. Widayati, and E. Goenarwo, “Typhonium flagelliforme decreases protein expression in murine breast cancer,” Universa Med., vol. 33, no. 3, pp. 163–170, 2014.
[26] D. Ravishankar, A. K. Rajora, F. Greco, and H. M. I. Osborn, “Flavonoids as prospective compounds for anti-cancer therapy,” Int. J. Biochem. Cell Biol., vol. 45, no. 12, pp. 2821–2831, 2013, doi: 10.1016/j.biocel.2013.10.004.
[27] P. Sisodia and K. Hasan, “Corrosion Inhibition of Mild Steel by Phytochemicals in Acidic Media,” J. Bio- Tribo-Corrosion, vol. 7, no. 1, 2013, doi: 10.1007/s40735-020-00439-7.
[28] E. Katrin, H. Winarno, Susanto, and F. N., “Karakteristika dan Khasiat Daun Keladi Tikus ( Typhonium divaricatum ( L .) Decne ) Iradiasi,” J. Ilm. Apl. Isot. dan Radiasi, vol. 8, no. 1, pp. 31–35, 2012, [Online]. Available: http://jurnal.batan.go.id/index.php/jair/article/view/492.
[29] N. M. Putram, I. Setyaningsih, K. Tarman, and M. Nursid, “Anticancer Activity from Active Fraction of Sea Cucumber,” vol. 20, pp. 53–62, 2017.
[30] A. Putra, Tjahjono, and Winarto, “Ekstrak Keladi Tikus (Typhonium flagelliforme) Fraksi Diklorometanolik dan Ekspresi Caspase-3 dan p21 Cell-Line Kanker Payudara MCF-7,” Media Med. Indones., vol. 46, no. 14, pp. 6–11, 2012.
[31] C. Li et al., “Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate,” Carcinogenesis, vol. 32, no. 8, pp. 1251–1258, 2011, doi: 10.1093/carcin/bgr092.
[32] E.-S. Abdel-Hameed, S. Bazaid, M. Shohayeb, M. El-Sayed, and E. Eman, “Phytochemical Studies and Evaluation of Antioxidant, Anticancer and Antimicrobial Properties of Conocarpus erectus L. Growing in Taif, Saudi Arabia,” European J. Med. Plants, vol. 2, no. 2, pp. 93–112, 2012, doi: 10.9734/ejmp/2012/1040.
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2021-12-08
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Ningrum, M. P., Dianita, P. S., & Agusta, H. F. (2021). The Effectiveness of Typhonium Flagelliforme for Breast Cancer: A Narrative Review. Prosiding University Research Colloquium, 387–398. Retrieved from https://repository.urecol.org/index.php/proceeding/article/view/1598
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Copyright (c) 2021 Meiliana Purnama Ningrum, Puspita Septie Dianita, Herma Fanani Agusta
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