Risk Factor of Falling in Individual with Type 2 Diabetes Mellitus
Keywords:
Risk factor, falling, type 2 diabetes mellitusAbstract
Background: Diabetes Mellitus (DM) is characterized by hyperglycemia. Type 2 diabetes mellitus (T2DM) is a common type of DM. It gives microvascular and macrovascular complications in the body. The diabetic peripheral neuropathy (DPN) is declared as the highest complication of T2DM, about two third cases of DM. It impacts to high risk of falling. As well the duration of DM and body balance also contributed to balance stability. Poor of those factors increase the risk of falling. However, previous studies have not declared the dominant factor contributing to falling in individuals with T2DM. Purpose: The purpose of this study was to determine the dominant factors contributing in the risk factors of falling risk in individuals with T2DM. Methods: The patients confirmed T2DM by medical diagnosis and had 5 years above of T2DM. The glycemic level was set by taken blood sample from intravenous after fasted for 8 hours. The Michigan Neuropathy Screening Instrument (MNSI) was used to screen the DPN. The static balance was measured by the Berg Balance Scale (BBS), while dynamic balance was measured by Time Up and Go test. The risk of falling was confirmed by the cut score of the Timed Up and Go test. This study has done in DM community, Surakarta, Central Java, Indonesia. Results: The correlation test showed the duration of DM and DPN had correlation with balance. had a contribution to the risk of falling significantly (p-value <0.05). The Logistic Regression Model presented the duration of DM (OR : 1.008, p-value=0.001, 95% CI = 1.518 – 4.943) dan balance (OR = 0.317, p-value = 0.001, 955 CI = 1.518 – 4.943) influenced the risk of falling in individuals with T2DM. Conclusion: The longer suffer of DM and uncontrol glycemic level induced the development of DPN. The duration of suffering from DM must be accompanied by good lifestyle management to avoid development some complications of DM.
References
ADA. (2018). Glycemic Targets: Standards of Medical Care in Diabetes-2018. Diabetes Care,
(Suppl 1), S55-s64. doi:10.2337/dc18-S006
Agrawal, Y., Carey, J. P., Della Santina, C. C., Schubert, M. C., & Minor, L. B. (2009).
Disorders of balance and vestibular function in US adults: data from the National
Health and Nutrition Examination Survey, 2001-2004. Arch Intern Med, 169(10),
-944. doi:10.1001/archinternmed.2009.66
Agrawal, Y., Carey, J. P., Della Santina, C. C., Schubert, M. C., & Minor, L. B. (2010).
Diabetes, vestibular dysfunction, and falls: analyses from the National Health and
Nutrition Examination Survey. Otol Neurotol, 31(9), 1445-1450.
doi:10.1097/MAO.0b013e3181f2f035
Agrawal, Y., Ward, B. K., & Minor, L. B. (2013). Vestibular dysfunction: prevalence, impact
and need for targeted treatment. J Vestib Res, 23(3), 113-117. doi:10.3233/ves-130498
Al-Hariri, M. (2016). The pathophysiological mechanisms of diabetic otopathy. Journal of
Taibah University Medical Sciences. doi:10.1016/j.jtumed.2015.12.006
Allen, K., & McFarland, M. (2020). How Are Income and Education Related to the Prevention
and Management of Diabetes? J Aging Health, 32(9), 1063-1074.
doi:10.1177/0898264319879608
Arnetz, L., Ekberg, N. R., & Alvarsson, M. (2014). Sex differences in type 2 diabetes: focus on
disease course and outcomes. Diabetes Metab Syndr Obes, 7, 409-420.
doi:10.2147/dmso.S51301
Bokan-Mirkovic, V., Skaric-Karanikic, Z., Nejkov, S., Vukovic, M., & Cirovic, D. (2017).
Diabetic Polyneuropathy and Risk of Falls: Fear of Falling and Other Factors. Acta
Clin Croat, 56(4), 721-727. doi:10.20471/acc.2017.56.04.20
Boulton, A. J., Malik, R. A., Arezzo, J. C., & Sosenko, J. M. (2004). Diabetic somatic
neuropathies. Diabetes Care, 27(6), 1458-1486. doi:10.2337/diacare.27.6.1458
Brands, A. M., Kessels, R. P., de Haan, E. H., Kappelle, L. J., & Biessels, G. J. (2004). Cerebral
dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and bloodglucose
levels. Eur J Pharmacol, 490(1-3), 159-168. doi:10.1016/j.ejphar.2004.02.053
Brown, S. J., Handsaker, J. C., Bowling, F. L., Boulton, A. J., & Reeves, N. D. (2015). Diabetic
peripheral neuropathy compromises balance during daily activities. Diabetes Care,
(6), 1116-1122. doi:10.2337/dc14-1982
Brown, S. J., Handsaker, J. C., Bowling, F. L., Maganaris, C. N., Boulton, A. J., & Reeves, N.
D. (2014). Do patients with diabetic neuropathy use a higher proportion of their
maximum strength when walking? J Biomech, 47(15), 3639-3644.
doi:10.1016/j.jbiomech.2014.10.005
Cabeza, R. (2002). Hemispheric asymmetry reduction in older adults: the HAROLD model.
Psychol Aging, 17(1), 85-100. doi:10.1037//0882-7974.17.1.85
Cameron, N. E., Eaton, S. E., Cotter, M. A., & Tesfaye, S. (2001). Vascular factors and
metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia,
(11), 1973-1988. doi:10.1007/s001250100001
Chamarthi, B., Williams, G. H., Ricchiuti, V., Srikumar, N., Hopkins, P. N., Luther, J. M., . .
. Thomas, A. (2011). Inflammation and hypertension: the interplay of interleukin-6,
dietary sodium, and the renin-angiotensin system in humans. Am J Hypertens,
(10), 1143-1148. doi:10.1038/ajh.2011.113
Chaudhary, G. M. D., Tameez Ud Din, A., Chaudhary, F. M. D., Tanveer, A., Siddiqui, K. H.,
Tameez Ud Din, A., . . . Nawaz, F. (2019). Association of Obesity Indicators with
Hypertension in Type 2 Diabetes Mellitus Patients. Cureus, 11(7), e5050.
doi:10.7759/cureus.5050
Chentli, F., Azzoug, S., & Mahgoun, S. (2015). Diabetes mellitus in elderly. Indian J
Endocrinol Metab, 19(6), 744-752. doi:10.4103/2230-8210.167553
Coughlin, S. S., Calle, E. E., Teras, L. R., Petrelli, J., & Thun, M. J. (2004). Diabetes mellitus
as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol,
(12), 1160-1167. doi:10.1093/aje/kwh161
Cunha, J. M., Jolivalt, C. G., Ramos, K. M., Gregory, J. A., Calcutt, N. A., & Mizisin, A. P.
(2008). Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats:
effects of aldose reductase inhibition, insulin, and neurotrophic factors. Metabolism,
(7), 873-881. doi:10.1016/j.metabol.2008.01.021
D'Silva, L. J., Lin, J., Staecker, H., Whitney, S. L., & Kluding, P. M. (2016). Impact of Diabetic
Complications on Balance and Falls: Contribution of the Vestibular System. Phys
Ther, 96(3), 400-409. doi:10.2522/ptj.20140604
El-Gohary, M., Pearson, S., McNames, J., Mancini, M., Horak, F., Mellone, S., & Chiari, L.
(2013). Continuous monitoring of turning in patients with movement disability.
Sensors (Basel), 14(1), 356-369. doi:10.3390/s140100356
Emdin, C. A., Anderson, S. G., Woodward, M., & Rahimi, K. (2015). Usual Blood Pressure
and Risk of New-Onset Diabetes: Evidence From 4.1 Million Adults and a Meta-
Analysis of Prospective Studies. J Am Coll Cardiol, 66(14), 1552-1562.
doi:10.1016/j.jacc.2015.07.059
Epstein, M., & Sowers, J. R. (1992). Diabetes mellitus and hypertension. Hypertension, 19(5),
-418. doi:10.1161/01.hyp.19.5.403
Gioacchini, F. M., Albera, R., Re, M., Scarpa, A., Cassandro, C., & Cassandro, E. (2018).
Hyperglycemia and diabetes mellitus are related to vestibular organs dysfunction:
truth or suggestion? A literature review. Acta Diabetol, 55(12), 1201-1207.
doi:10.1007/s00592-018-1183-2
Gore, M., Brandenburg, N. A., Dukes, E., Hoffman, D. L., Tai, K. S., & Stacey, B. (2005). Pain
severity in diabetic peripheral neuropathy is associated with patient functioning,
symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage, 30(4),
-385. doi:10.1016/j.jpainsymman.2005.04.009
Government., A., & Welfare, A. I. o. H. a. (2013). Diabetes and Disability : impairments,
activity limitations, participation restrictions and comorbidities DIABETES
SERIES.
Harrison, S. A. (2006). Liver disease in patients with diabetes mellitus. J Clin Gastroenterol,
(1), 68-76. doi:10.1097/01.mcg.0000190774.91875.d2
Hausdorff, J. M., Rios, D. A., & Edelberg, H. K. (2001). Gait variability and fall risk in
community-living older adults: a 1-year prospective study. Arch Phys Med Rehabil,
(8), 1050-1056. doi:10.1053/apmr.2001.24893
Hewston, P., & Deshpande, N. (2016). Falls and Balance Impairments in Older Adults with
Type 2 Diabetes: Thinking Beyond Diabetic Peripheral Neuropathy. Can J Diabetes,
(1), 6-9. doi:10.1016/j.jcjd.2015.08.005
Hewston, P., & Deshpande, N. (2018). Fear of Falling and Balance Confidence in Older Adults
With Type 2 Diabetes Mellitus: A Scoping Review. Can J Diabetes, 42(6), 664-670.
doi:10.1016/j.jcjd.2018.02.009
Horak, F. B. (2006). Postural orientation and equilibrium: what do we need to know about
neural control of balance to prevent falls? Age Ageing, 35 Suppl 2, ii7-ii11.
doi:10.1093/ageing/afl077
Kalyani, R. R., Metter, E. J., Egan, J., Golden, S. H., & Ferrucci, L. (2015). Hyperglycemia
predicts persistently lower muscle strength with aging. Diabetes Care, 38(1), 82-90.
doi:10.2337/dc14-1166
Kanade, R. V., van Deursen, R. W., Harding, K., & Price, P. (2006). Walking performance in
people with diabetic neuropathy: benefits and threats. Diabetologia, 49(8), 1747-1754.
doi:10.1007/s00125-006-0309-1
King, H., Aubert, R. E., & Herman, W. H. (1998). Global burden of diabetes, 1995-2025:
prevalence, numerical estimates, and projections. Diabetes Care, 21(9), 1414-1431.
doi:10.2337/diacare.21.9.1414
Komalasari, D. R., Vongsirinavarat, M., Hiengkaew, V., & Nualnim, N. (2022). The
Adaptation of Participation Scale Short Simplified Questionnaire into Indonesian
Language and the Psychometric Properties in Individuals with Type 2 Diabetes
Mellitus with Vestibular Dysfunction. Rehabil Res Pract, 2022, 2565833.
doi:10.1155/2022/2565833
Kraiwong, R., Vongsirinavarat, M., Hiengkaew, V., & von Heideken Wagert, P. (2019). Effect
of Sensory Impairment on Balance Performance and Lower Limb Muscle Strength in
Older Adults With Type 2 Diabetes. Ann Rehabil Med, 43(4), 497-508.
doi:10.5535/arm.2019.43.4.497
Mancini, M., & Horak, F. B. (2010). The relevance of clinical balance assessment tools to
differentiate balance deficits. Eur J Phys Rehabil Med, 46(2), 239-248.
Meigs, J. B., Hu, F. B., Rifai, N., & Manson, J. E. (2004). Biomarkers of endothelial
dysfunction and risk of type 2 diabetes mellitus. Jama, 291(16), 1978-1986.
doi:10.1001/jama.291.16.1978
Mihardja, L., Soetrisno, U., & Soegondo, S. (2014). Prevalence and clinical profile of diabetes
mellitus in productive aged urban Indonesians. J Diabetes Investig, 5(5), 507-512.
doi:10.1111/jdi.12177
Min, H., Chang, J., & Balkrishnan, R. (2010). Sociodemographic risk factors of diabetes and
hypertension prevalence in republic of Korea. Int J Hypertens, 2010.
doi:10.4061/2010/410794
Moslemi-Haghighi, Ghafarinejad, Hemmati, Saadat, Oorangi, Torabi, & Mohammadzadeh.
(2015). Evaluation of Ankle Joint Proprioception and Balance in Patients with Type
Diabetes and Healthy Subjects. Journal of Rehabilitation Sciences and Research, 2,
-19.
Mozumdar, A., & Liguori, G. (2011). Persistent increase of prevalence of metabolic syndrome
among U.S. adults: NHANES III to NHANES 1999-2006. Diabetes Care, 34(1), 216-
doi:10.2337/dc10-0879
Müller, M. L., Albin, R. L., Kotagal, V., Koeppe, R. A., Scott, P. J., Frey, K. A., & Bohnen, N.
I. (2013). Thalamic cholinergic innervation and postural sensory integration function
in Parkinson's disease. Brain, 136(Pt 11), 3282-3289. doi:10.1093/brain/awt247
Nomura, T., Kawae, T., Kataoka, H., & Ikeda, Y. (2018). Assessment of lower extremity
muscle mass, muscle strength, and exercise therapy in elderly patients with diabetes
mellitus. Environ Health Prev Med, 23(1), 20. doi:10.1186/s12199-018-0710-7
O'Brien, P. D., Hinder, L. M., Sakowski, S. A., & Feldman, E. L. (2014). ER stress in diabetic
peripheral neuropathy: A new therapeutic target. Antioxid Redox Signal, 21(4), 621-
doi:10.1089/ars.2013.5807
Ogurtsova, K., da Rocha Fernandes, J. D., Huang, Y., Linnenkamp, U., Guariguata, L., Cho,
N. H., . . . Makaroff, L. E. (2017). IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract, 128, 40-50.
doi:10.1016/j.diabres.2017.03.024
Pasquali, R., Vicennati, V., Gambineri, A., & Pagotto, U. (2008). Sex-dependent role of
glucocorticoids and androgens in the pathophysiology of human obesity. Int J Obes
(Lond), 32(12), 1764-1779. doi:10.1038/ijo.2008.129
Petersen, R. C., Roberts, R. O., Knopman, D. S., Geda, Y. E., Cha, R. H., Pankratz, V. S., . . .
Rocca, W. A. (2010). Prevalence of mild cognitive impairment is higher in men. The
Mayo Clinic Study of Aging. Neurology, 75(10), 889-897.
doi:10.1212/WNL.0b013e3181f11d85
Pijpers, E., Ferreira, I., de Jongh, R. T., Deeg, D. J., Lips, P., Stehouwer, C. D., &
Nieuwenhuijzen Kruseman, A. C. (2012). Older individuals with diabetes have an
increased risk of recurrent falls: analysis of potential mediating factors: the
Longitudinal Ageing Study Amsterdam. Age Ageing, 41(3), 358-365.
doi:10.1093/ageing/afr145
Pinheiro, H. A., Vilaça, K. H. C., & Carvalho, G. d. A. (2015). Assessment of muscle mass,
risk of falls and fear of falling in elderly people with diabetic neuropathy %J
Fisioterapia em Movimento. 28, 677-683.
Prevalence of overweight and obesity among adults with diagnosed diabetes--United States,
-1994 and 1999-2002. (2004). MMWR Morb Mortal Wkly Rep, 53(45), 1066-1068.
Prevention, C. f. D. C. a., & (2011). National diabetes fact sheet: national estimates and
general information on diabetes and prediabetes in the United States. from U.S.
Department of Health and Human Services, Centers for Disease Control and
Prevention
Purwanti, O. S., Yetti, K., & Herawati, T. J. F. o. N. (2019). Relationship of visual impairment
and peripheral artery disease with the occurrence of diabetic foot ulcers in Dr.
Moewardi Hospital. 6(2), 157-160.
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., . . .
Acker, J. D. (2005). Regional brain changes in aging healthy adults: general trends,
individual differences and modifiers. Cereb Cortex, 15(11), 1676-1689.
doi:10.1093/cercor/bhi044
Raz, N., Rodrigue, K. M., & Haacke, E. M. (2007). Brain aging and its modifiers: insights from
in vivo neuromorphometry and susceptibility weighted imaging. Ann N Y Acad Sci,
, 84-93. doi:10.1196/annals.1379.018
Reis, J. P., Allen, N. B., Bancks, M. P., Carr, J. J., Lewis, C. E., Lima, J. A., . . . Schreiner, P.
J. (2018). Duration of Diabetes and Prediabetes During Adulthood and Subclinical
Atherosclerosis and Cardiac Dysfunction in Middle Age: The CARDIA Study.
Diabetes Care, 41(4), 731-738. doi:10.2337/dc17-2233
Rosyid, F. N., Muhtadi, M., Hudiyawati, D., Sugiyarti, S., & Rahman, A. F. (2022). Improving
Diabetic Foot Ulcer Healing with Adjuvant Bitter Melon Leaf Extract (Momordica
charantia L.). Open Access Maced J Med Sci, 10(T8), 122-126.
doi:10.3889/oamjms.2022.9503
Russell, J. W., & Zilliox, L. A. (2014). Diabetic neuropathies. Continuum (Minneap Minn),
(5 Peripheral Nervous System Disorders), 1226-1240.
doi:10.1212/01.CON.0000455884.29545.d2
Saxton, S. N., Clark, B. J., Withers, S. B., Eringa, E. C., & Heagerty, A. M. (2019). Mechanistic
Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose
Tissue. Physiol Rev, 99(4), 1701-1763. doi:10.1152/physrev.00034.2018
Shumway-Cook, A., Brauer, S., & Woollacott, M. (2000). Predicting the probability for falls
in community-dwelling older adults using the Timed Up & Go Test. Phys Ther, 80(9),
-903.
Sibley, K. M., Beauchamp, M. K., Van Ooteghem, K., Straus, S. E., & Jaglal, S. B. (2015).
Using the systems framework for postural control to analyze the components of
balance evaluated in standardized balance measures: a scoping review. Arch Phys
Med Rehabil, 96(1), 122-132.e129. doi:10.1016/j.apmr.2014.06.021
Silva, E. F. F., Ferreira, C. M. M., & Pinho, L. (2017). Risk factors and complications in type
diabetes outpatients. Rev Assoc Med Bras (1992), 63(7), 621-627. doi:10.1590/1806-
63.07.621
Tilling, L. M., Darawil, K., & Britton, M. (2006). Falls as a complication of diabetes mellitus
in older people. J Diabetes Complications, 20(3), 158-162.
doi:10.1016/j.jdiacomp.2005.06.004
Tsimihodimos, V., Gonzalez-Villalpando, C., Meigs, J. B., & Ferrannini, E. (2018).
Hypertension and Diabetes Mellitus: Coprediction and Time Trajectories.
Hypertension, 71(3), 422-428. doi:10.1161/hypertensionaha.117.10546
van Deursen, R. W., & Simoneau, G. G. (1999). Foot and ankle sensory neuropathy,
proprioception, and postural stability. J Orthop Sports Phys Ther, 29(12), 718-726.
doi:10.2519/jospt.1999.29.12.718
Vermeer, S. E., Heijer, T. D., Koudstaal, P. J., Oudkerk, M., Hofman, A., & Breteler, M. M.
(2003). Incidence and risk factors of silent brain infarcts in the population-based
Rotterdam Scan Study. Stroke, 34(2), 392-396.
doi:10.1161/01.str.0000052631.98405.15
Vongsirinavarat, M., Mathiyakom, W., Kraiwong, R., & Hiengkaew, V. (2020). Fear of
Falling, Lower Extremity Strength, and Physical and Balance Performance in Older
Adults with Diabetes Mellitus. Journal of diabetes research, 2020, 8573817.
doi:10.1155/2020/8573817
Wannamethee, S. G., Papacosta, O., Lawlor, D. A., Whincup, P. H., Lowe, G. D., Ebrahim, S.,
& Sattar, N. (2012). Do women exhibit greater differences in established and novel
risk factors between diabetes and non-diabetes than men? The British Regional Heart
Study and British Women's Heart Health Study. Diabetologia, 55(1), 80-87.
doi:10.1007/s00125-011-2284-4
WHO. (2016). Global report on diabetes
Wrobel, J. S., Crews, R. T., & Connolly, J. E. (2009). Clinical factors associated with a
conservative gait pattern in older male veterans with diabetes. J Foot Ankle Res, 2,
doi:10.1186/1757-1146-2-11
Yang, L., Shao, J., Bian, Y., Wu, H., Shi, L., Zeng, L., . . . Dong, J. (2016). Prevalence of type 2
diabetes mellitus among inland residents in China (2000-2014): A meta-analysis. J
Diabetes Investig, 7(6), 845-852. doi:10.1111/jdi.12514
Yang, W., Lu, J., Weng, J., Jia, W., Ji, L., Xiao, J., . . . He, J. (2010). Prevalence of diabetes
among men and women in China. N Engl J Med, 362(12), 1090-1101.
doi:10.1056/NEJMoa0908292
Zenker, J., Ziegler, D., & Chrast, R. (2013). Novel pathogenic pathways in diabetic
neuropathy. Trends Neurosci, 36(8), 439-449. doi:10.1016/j.tins.2013.04.008
Zhang, H., Ni, J., Yu, C., Wu, Y., Li, J., Liu, J., . . . Wang, J. (2019). Sex-Based Differences in
Diabetes Prevalence and Risk Factors: A Population-Based Cross-Sectional Study
Among Low-Income Adults in China. Front Endocrinol (Lausanne), 10, 658.
doi:10.3389/fendo.2019.00658
Zheng, Y., Ley, S. H., & Hu, F. B. (2018). Global aetiology and epidemiology of type 2 diabetes
mellitus and its complications. Nat Rev Endocrinol, 14(2), 88-98.
doi:10.1038/nrendo.2017.151
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