Cytotoxicity Study of Composite Restorative Materials in Dentistry


  • Dendy Murdiyanto Universitas Muhammadiyah Surakarta
  • Arny Try Kartinawati Universitas Muhammadiyah Surakarta
  • Dannu Larezha Universitas Muhammadiyah Surakarta


Composite resin is one of the dental restorative materials that is currently often used in
dental practice. Composite resin is currently widely used for restoration because it has a
color that almost resembles the color of natural teeth so that it will produce a very
satisfying aesthetic. However, composite resins also have several disadvantages,
including cytotoxicity. This literature review aims to determine whether dental
composite resin restoration materials are cytotoxic. Methacrylate-based resin monomers
such as Bis-GMA, TEGDMA, and UDMA are cytotoxic. Incomplete polymerization of
composite resins can produce residual monomers that will come into contact with the
oral environment and can cause irritation to the soft tissues of the oral cavity and also
the pulp. The composite resin monomer has cytotoxicity. The order of the most cytotoxic
composite resin monomers was Bis-GMA > UDMA > TEGDMA




How to Cite

Murdiyanto, D., Kartinawati, A. T., & Larezha, D. (2022). Cytotoxicity Study of Composite Restorative Materials in Dentistry. Prosiding University Research Colloquium, 456–462. Retrieved from