Korelasi Kadar Glukosa Darah dengan Profil Hematologi Pada Pasien Diabetes Mellitus dengan Ulkus Diabetikum
Keywords:
Diabetes mellitus, Glukosa darah, Profil hematologi, Ulkus diabetikumAbstract
Diabetes mellitus (DM) merupakan kelainan metabolik yang dapat menyebabkan berbagai komplikasi, termasuk ulkus diabetikum. Hiperglikemia yang persisten dapat mengakibatkan kelainan vaskuler dan metabolik serta mempengaruhi kinerja sumsum tulang sehingga menyebabkan terjadinya perubahan pada profil hematologi pada pasien diabetes mellitus. Penelitian ini bertujuan untuk mengetahui korelasi kadar glukosa darah dengan profil hematologi pada pasien DM dengan ulkus diabetikum. Jenis penelitian ini adalah analisis kuantitatif dengan metode eksperimental laboratorik dengan menggunakan 30 sampel darah pasien diabetes mellitus di Rumah Luka Wonoayu Sidoarjo, yang diambil secara purposive sampling. Pemeriksaan profil hematologi menggunakan metode otomatis dengan alat hematology analyzer, pemeriksaan glukosa darah dengan metode point of care testing (POCT), pemeriksaan laju endap darah dengan metode Westergreen. Pada uji korelasi regresi berganda diperoleh hasil terdapat hubungan bermakna antara glukosa darah dengan hemoglobin (p = 0,013), hematokrit (p = 0,011), MCV (p = 0,044), MCH (p = 0,048), dan LED (p = 0,010). Namun tidak terdapat hubungan bermakna antara glukosa darah dengan jumlah eritrosit (p = 0,997), MCHC (p = 0,152), jumlah leukosit (p = 0,082), dan jumlah trombosit (p = 0,484). Kesimpulan penelitian adalah terdapat korelasi yang sedang (r = 0,422) antara kadar glukosa darah dengan profil hematologi pada pasien diabetes mellitus dengan ulkus diabetikum.
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Haematological Profile of Diabetes and
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Endocrinology. 2015; 1(7): 1-5.
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Qiu Q, Yang M, Liang J. Six-Year
Follow-Up Study On The Association
Between White Blood Cell Count and
Fasting Blood Glucose Level in Chinese
Adults: A Community-Based Health
Examination Survey. Diabetes Metab Res
Rev. 2019; 35(e3125): 1-6
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NVD, Rietveld AP, Lim AH, Westerman
EM, Herder WWD, Cabezas MC.
Glucose-Dependent Leukocyte
Activation in Patients With Type 2
Diabetes Mellitus, Familial Combined
Hyperlipidemia and Healthy Controls.
Metabolism Clinical And Experimental.
2015; 64(2): 213-7.
[25] Naredi M, Jhavar D, Krishnan D. Study
of Relationship Between WBC Count
and Diabetic Complications.
International Journal of Advances in
Medicine. 2017; 4(4): 1128-1132.
[26] Mardia AI, Gatot D, Lindarto D.
Comparison Platelet Indices in Diabetic
Patients With and Without Diabetic Foot
Ulcer. IOP Conf. Series: Earth and
Environmental Science 125 012134.
2018; p. 1-5.
[27] Jayalakshmi N, Praveen D, Chowdary
PR, Aanandhi MV. A Prospective Cross-
Sectional Study on The Clinical
Association of Serum Fibrinogen,
Platelets, and Serum Albumin In Diabetic
Foot Ulcer. Drug Invention Today. 2019;
12(11): 2682-2685.
[28] Guo S, Wang M, Yu Y, Yang Y, Zeng F,
Sun F, Li Q, He M, Li Y, Wen J, Gong
W, Zhang Z. The Association of
Erythrocyte Sedimentation Rate, High-
Sensitivity C-Reactive Protein and
Diabetic Kidney Disease In Patients With
Type 2 Diabetes. BMC Endocrine
Disorders. 2020; 20(103): 1-8.
[29] Bikramjit P, Raveender N, Sudipta P.
The Importance of Hba1c and
Erythrocyte Sedimentation Rate as
Prognostic Factors in Predicting The
Outcome of Diabetic Foot Ulcer Disease.
International Journal of Advances in
Medicine. 2017; 4(1): 137-142.
Standards of Medical Care in Diabetes.
USA: American Diabetes Association;
2014. 581-590.
[2] International Diabetes Federation (IDF).
IDF Diabetes Atlas. Ninth Edition.
Belgium: International Diabetes
Federation; 2019. 1-168.
[3] Kemenkes, RI. Riset Kesehatan Dasar:
Riskesdas 2018. Jakarta: Badan
Penelitian dan Pengembangan Kesehatan
Kementrian Kesehatan RI; 2018. 1-628.
[4] Darwis P, Putra JC, Pratama D, Kekalih
A. Relationship Between Leukocyte,
ESR, and CRP Infection Markers with
Changes in Wound Wagner 2 and 3
Diabetic Foot Ulcers. Journal of
Indonesian Society for Vascular and
Endovascular Surgery. 2020; 1(2): 26-
29.
[5] Semadi IN, Irawan H. Blood Glucose
and Lipid Profile in Patients with
Diabetic Foot Ulcer that Underwent
Hyperbaric Oxygen Therapy. Bali Medical Journal. 2017; 6(2): 405-
408.
[6] Biadgo B, Melku M, Abebe SM, Abebe
M. Hematological Indices And Their
Correlation With Fasting Blood Glucose
Level And Anthropometric
Measurements In Type 2 Diabetes
Mellitus Patients In Gondar, Northwest
Ethiopia. Diabetes, Metabolic Syndrome
and Obesity: Targets and Therapy. 2016;
Vol 9: 91-99.
[7] Mirza S, Hossain M, Mathews C,
Martinez P, Pino P, Gay JL, Rentfro A,
McCormick JB, Hoch SPF. Type 2-
Diabetes is Associated With Elevated
Levels Of TNF-Alpha, IL-6 and
Adiponectin and Low Levels of Leptin In
a Population of Mexican Americans: a
Cross-Sectional Study. Cytokine. 2012;
57(1):136-142.
[8] Lindarto D, Syafril S, Gatot D. The
Correlation between Glycemic
Characteristic and Erythrocyte Indices in
Obesity. Indones Biomed J. 2016; 8(3):
167-72.
[9] Yang JK, Feng Y, Yuan MY, Yuan SY,
Fu HJ, Wu BY, Sun GZ, Yang GR,
Zhang XL, Wang L, Xu X, Xu XP, Chan
JCN. Plasma glucose levels and diabetes
are independent predictors for mortality
and morbidity in patients with SARS.
Diabetic Medicine. 2006; 23(6): 623-628.
[10] Yuhelma, Hasneli Y, Nauli FA.
Identifikasi dan Analisis Komplikasi
Makrovaskuler dan Mikrovaskuler Pada
Pasien Diabetes Mellitus. Jurnal Online
Mahasiswa Perpustakaan Fakultas
Keperawatan. 2015; 2(1): 569-579.
[11] Fatimah RN. Diabetes Melitus Tipe 2. J
Majority. 2015; 4(5): 93-101.
[12] Mildawati, Diani N, Wahid A.
Relationship Between Age, Gender and
Duration Of Diabetes Patients With The
Incidence Of Diabetic Peripheral
Neuropathy. Caring Nursing Journal.
2019; 3(2): 31-37.
[13] Damayanti S. Diabetes Mellitus &
Penatalaksanaan Keperawatan. Cetakan
1. Yogyakarta: Nuha Medika; 2015.
[14] Smeltzer SC, Bare BG, Hinkle J, Cheever
KH. Brunner and Suddarth’s: Textbook
of Medical-Surgical Nursing (12th ed.).
Philadelphia: Lippincott Wiliams &
Walkins; 2010.
[15] Yosmar R, Almasdy D, Rahma F. Survei
Risiko Penyakit Diabetes Mellitus
Terhadap Masyarakat Kota Padang.
Jurnal Sains Farmasi & Klinis. 2018;
5(2): 134-141.
[16] Chinmay S, Manjula SD, Bekur R,
Raghavendra RK. Association of
Increased Levels of Glycated
Hemoglobin with Variations in Red
Blood Cell Parameters in Diabetes
Mellitus. International Journal of
Advanced Research. 2015; 3(6): 31-
37.
[17] Bharathi K. Study Of Hematological
Profile And Its Signicance In Type 2
Diabetes Mellitus Patients. Journal of
Diagnostic Pathology and Oncology.
2016; 1(1): 14-17.
[18] Wang ZS, Song ZC, Bai JH, Li F, Wu T,
Qi J, Hu J. Red blood cell count as an
indicator of microvascular complications
in Chinese patients with type 2 diabetes
mellitus patients. Vacs health risk manag.
2013; 9: 237-243.
[19] Alamri BN, Bahabri A, Aldereihim AA,
Alabduljabbar M, Alsubaie MM,
Alnaqeb D, Almogbel E, Metias NS,
Alotaibi OA, Al-Rubeaan K.
Hyperglycemia Effect on Red Blood
Cells Indices. European Review for
Medical and Pharmacological Sciences.
2019; Vol. 23: 2139-2150.
[20] Frykberg RG. Diabetic Foot Ulcer:
Pathogenesis and Management. Am Fam
Physician. 2002; 66(9): 1655-1662.
[21] Kumar HS, Srinivasa SV, Prabhakar K.
Haematological Profile of Diabetes and
Non-Diabetes Patients in Rural Tertiary
Centre. International Journal of
Advances in Medicine. 2017; 4(5): 1271-
1275.
[22] Asmah RH, Yeboah G, Asare-Anane H,
Antwi-Baffour S, Archampong TN,
Brown CA, Amegatcher G, Adjei DN,
Dzudzor B, Akpalu J, Ayeh-Kumi PF.
Relationship Between Oxidative Stress
and Haematological Indices in Patients
with Diabetes in The Ghanaian
Population. Clinical Diabetes and
Endocrinology. 2015; 1(7): 1-5.
[23] Zang X, Meng X, Wang Y, Jin X, Wu T,
Liu X, Geng H, Xu W, Wang Y, Teng F,
Qiu Q, Yang M, Liang J. Six-Year
Follow-Up Study On The Association
Between White Blood Cell Count and
Fasting Blood Glucose Level in Chinese
Adults: A Community-Based Health
Examination Survey. Diabetes Metab Res
Rev. 2019; 35(e3125): 1-6
[24] Vries MAD, Alipour A, Klop B, Geijn
GJMVD, Janssen HW, Njo TL, Meulen
NVD, Rietveld AP, Lim AH, Westerman
EM, Herder WWD, Cabezas MC.
Glucose-Dependent Leukocyte
Activation in Patients With Type 2
Diabetes Mellitus, Familial Combined
Hyperlipidemia and Healthy Controls.
Metabolism Clinical And Experimental.
2015; 64(2): 213-7.
[25] Naredi M, Jhavar D, Krishnan D. Study
of Relationship Between WBC Count
and Diabetic Complications.
International Journal of Advances in
Medicine. 2017; 4(4): 1128-1132.
[26] Mardia AI, Gatot D, Lindarto D.
Comparison Platelet Indices in Diabetic
Patients With and Without Diabetic Foot
Ulcer. IOP Conf. Series: Earth and
Environmental Science 125 012134.
2018; p. 1-5.
[27] Jayalakshmi N, Praveen D, Chowdary
PR, Aanandhi MV. A Prospective Cross-
Sectional Study on The Clinical
Association of Serum Fibrinogen,
Platelets, and Serum Albumin In Diabetic
Foot Ulcer. Drug Invention Today. 2019;
12(11): 2682-2685.
[28] Guo S, Wang M, Yu Y, Yang Y, Zeng F,
Sun F, Li Q, He M, Li Y, Wen J, Gong
W, Zhang Z. The Association of
Erythrocyte Sedimentation Rate, High-
Sensitivity C-Reactive Protein and
Diabetic Kidney Disease In Patients With
Type 2 Diabetes. BMC Endocrine
Disorders. 2020; 20(103): 1-8.
[29] Bikramjit P, Raveender N, Sudipta P.
The Importance of Hba1c and
Erythrocyte Sedimentation Rate as
Prognostic Factors in Predicting The
Outcome of Diabetic Foot Ulcer Disease.
International Journal of Advances in
Medicine. 2017; 4(1): 137-142.
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Published
2021-05-27
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Aliviameita, A., Puspitasari, P., Purwanti, Y., & Ariyanti, S. (2021). Korelasi Kadar Glukosa Darah dengan Profil Hematologi Pada Pasien Diabetes Mellitus dengan Ulkus Diabetikum. Prosiding University Research Colloquium, 791–799. Retrieved from https://repository.urecol.org/index.php/proceeding/article/view/1479
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Copyright (c) 2021 Andika Aliviameita, P Puspitasari, Yanik Purwanti, Silvia Ariyanti
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