Efek Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Binahong Terhadap Penyembuhan Luka Fase Proliferasi Pada Mencit Diabetik

  • Eka Sakti Wahyuningtyas Universitas Muhammadiyah Magelang
  • N Nasruddin Universitas Muhammadiyah Semarang
  • Heni Setyowati Esti Rahayu Universitas Muhammadiyah Semarang
  • Heni Lutfiyati Universitas Muhammadiyah Magelang
  • Isabella Meliawati Sikumbang Universitas Ahmad Dahlan
  • Laela Hayu Nurani Universitas Muhammadiyah Semarang
  • Arum Kartikadewi Universitas Muhammadiyah Semarang
  • Nia Salsabila Universitas Muhammadiyah Magelang
  • Gela Setya Ayu Putri Universitas Muhammadiyah Magelang
  • Putri Kurniasiwi Universitas Muhammadiyah Semarang
  • Devi Kemala Dewi Universitas Aisyiyah Yogyakarta
Keywords: Plasma medicine; RONS; PAW; Natural product; Diabetic wound


Plasma medicine is a relatively new and multidisciplinary study
involving the study of plasma science, biomedicine, pharmacy, and
other health sciences to utilizing plasma for medical therapy. Plasma
is the fourth substance, after solids, liquids, and gases. Plasma can
produce biological molecules of Reactive Oxygen and Nitrogen
Species (RON) which, if controlled in the right dose, can be
beneficial for health. This animal study examines the effect of
combinative treatment of medicine plasma and binahong leaf extract
on proliferation phase wound healing in a diabetic test model. The
study used Balb mice 7-8 years old which were induced by STZ with
acute wounds which were divided into 4 groups, namely the wound
group of diabetic mice without treatment (C), the group of diabetic
mice with the treatment of binahong leaf extract (B), the group of
combined treatment wounds plasma jet (P) and the wound group of
diabetic mice treated with a combination of plasma and, binahong
leaf extract (PB). Binahong leaf extract concentration 1% in DMSO
solvent. The jet type medicine plasma treatment was carried out
every day from day 0 to day 6. Macroscopic observation of the
wound was carried out every day from day 0 to day 7. On day 7 it
appears that the size of the wound area for P is much smaller than
for C, B, and PB. The size of area B and PB is relatively the same,
but smaller than C. The results of this study indicate that the
binahong leaf extract tends to inhibit the performance of medicine
plasma in accelerating the healing of the proliferation phase.