Efektivitas Gel Ekstrak Tangkai dan Daun Talas (Colocasia esculenta) Terhadap Penyembuhan Luka Diabetes
Keywords:
Colocasia esculenta, talas, luka, luka diabetesAbstract
Luka diabetes merupakan salah satu komplikasi diabetes mellitus (DM) yang berisiko mengalami infeksi dan dapat berakhir amputasi. Di Indonesia, prevalensi DM yang tinggi dan banyak terjadi pada usia produktif dapat mengganggu produktfitas bangsa. Pengobatan luka diabetes menggunakan antibiotik mempunyai efek samping iritasi kulit, membutuhkan banyak biaya, dan dilaporkan semakin banyak bakteri yang resisten. Penelitian ini dilakukan untuk mengetahui potensi ekstrak tanaman talas (Colocasia esculenta) dalam bentuk sediaan gel terhadap penyembuhan luka diabetes. Metode penelitian ini berupa literature review yang dilakukan secara sistematis melalui penelusuran hasil publikasi ilmiah menggunakan database. Hasil penelitian ini didapatkan bahwa ekstrak tanaman talas memiliki kandungan yang dapat mempercepat penyembuhan luka dengan membantu regenerasi sel kulit. Tangkai daun talas dapat mempercepat penyembuhan luka sayat, daun talas mempercepat penyembuhan luka terkontaminasi. Tidak hanya bagian tangkai dan daun, namun bagian umbi juga terbukti dapat mempercepat penyembuhan luka bakar dan luka terbuka. Tangkai dan daun talas (Colocasia esculenta) memiliki aktivitas antibakteri pada bakteri yang menjadi etiologi luka diabetes terinfeksi. Aktivitas antioksidan dapat melindungi sel-sel kulit dari kerusakan oksidatif dan mempercepat pemulihan luka dalam keadaan inflamasi, sehingga berpotensi mempercepat penyembuhan luka diabetes. Sediaan gel efektif menjaga kelembapan luka diabetes dan menunjukan peningkatan prolifesi sel, kepadatan kolagen sehingga dapat memberikan lingkungan yang mendukung proses penyembuhan luka diabetes.
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[18] Mawarsari, T. Uji Aktivitas Penyembuhan Luka BakarEkstrakEtanol Umbi Talas Jepang (Colocasia esculenta (L.) Schoot var. antiquorum Pada Tikus Putih (Rattus novergicus) Jantan Galur Sprauge Dawley. Thesis. UIN Syarif Hidayatullah Jakarta; 2015.
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[20] Muharty, Annisya. Pengaruh Aplikasi Ekstrak Daun Talas (Colocasia esculenta L. Schott) Terhadap Penyembuha Luka Terkontaminasi Bakteri Staphylococcus aureus Melalui Pemeriksaan Neutrofil, Makrofag, Reepitelisasi. Thesis. Fakultas Kedokteran Gigi, Universitas Padjajaran Bandung; 2019.
[21] Marchianti, A. C. N. Gel Formulations Of Merremia Mammosa (Lour.) Accelerated Wound Healing Of The Wound In Diabetic Rats. Journal of Traditional and Complementary Medicine. 2019; doi: 10.1016/j.jtcme. 2019.12.002.
[22] Gomes, A. et al. Wound-healing peptides for treatment of chronic diabetic foot ulcers and other infected skin injuries. Molecules. 2017; 22(10). 1–18.
[23] Sun, X. et al. Maggot debridement therapy promotes diabetic foot wound healing by up-regulating endothelial cell activity. Journal of Diabetes and its Complications. 2016; 30(2): 318–322.
[24] Dhanraj, N. et al. Phytochemical screening and Antibacterial Activity of Western Region wild leaf Colocasia esculenta. International Research Journal of Biological Sciences Int. Res. J. Biological Sci. 2013; 2(10): 2278–3202.
[25] Chakraborty, P. et al. Research Article Cytotoxicity and Antimicrobial Activity of Colocasia esculenta. Journal of Chemical and Pharmaceutical Research. 2015; 7(12): 627-635.
[26] Fadlila, Wildan N., Kiki Mulkiya, Y., Syafnir, L. Identifikasi Senyawa Aktif Antibakteri dengan Metode Bioautografi Klt terhadap Ekstrak Etanol Tangkai Daun Talas (Colocasia esculenta (L.) Schott). Prosiding Penelitian Spesia Unisba. 2015. p. 583–590.
[27] Al Kaf, A. G. et al. Phytochemical Analysis and Antimicrobial Activity of Colocasia esculenta (Taro) Medicinal Plant Leaves Used in Folk Medicine for Treatment of Wounds and Burns in Hufash District Al Mahweet Governorate–Yemen. Universal Journal of Pharmaceutical Research. 2019; 4(2): 29–33.
[28] Singh, B., Namrata and Lokendra Kumar, S. C. D. Antibacterial and Antifungal Activity of Colocasia esculenta Aqueous Extract. Journal of Pharmacy Research. 2011;4(5): 1459–1460.
[29] Umadevi, S., Kumar, S., Mariya. N., Easow, J. M., Kandhakumari, G., Sriangaraj, S., Raj, Sruthi, and Stephen, S. Microbiological Study Of Diabetic Foot Infections. 2011; 2(1): 12–17
[30] Goncalves, R. F. et al. Influence of taro (Colocasia esculenta L. Shott) growth conditions on the phenolic composition and biological properties. Food Chemistry. 2013; 141(4): 3480–3485.
[31] Leong, A. C. N. et al. Flavonoid glycosides in the shoot system of Okinawa Taumu (Colocasia esculenta S.). Food Chemistry. 2010;119(2): 630–635.
[32] Kartika, R. W. et al. Perawatan Luka Kronis dengan Modern Dressing. Perawatan Luka Kronis Dengan Modern Dressing. 2015; 42(7): 546–550.
[33] Marchianti, A. C. N. et al. Gel Formulations Of Merremia Mammosa (Lour.) Accelerated Wound Healing Of The Wound In Diabetic Rats. Journal of Traditional and Complementary Medicine. 2019; doi: 10.1016/j.jtcme. 2019.12.002.
[34] Fujiastuti, T. and Sugihartini, N. Sifat Fisik Dan Daya Iritasi Gel Ekstrak Etanol Herba Pegagan (Centella Asiatica L.) Dengan Variasi Jenis Gelling Agent Physical. Pharmacy. 2015; 12(01): 11–20.
[35] Lai, J. C. Y. et al. Treatment For Diabetic Ulcer Wounds Using A Fern Tannin Optimized Hydrogel Formulation With Antibacterial And Antioxidative Properties. Journal of Ethnopharmacology. 2016; 189: 277–289.
[36] Andarini, Y. N. and Risliawati, A. Variabilitas Karakter Morfologi Plasma Nutfah Talas (Colocasia esculenta) Lokal Pulau Jawa (Morphological Character Variability of Javanese Local Taro [Colocasia esculenta] Germplasm ). Buletin Plasma Nutfah. 2018; 24(1): 63-76.
[2] Kementerian Kesehatan Indonesia. Profil Kementerian Kesehatan Indonesia. Kementerian Kesehatan RI; 2020.
[3] International Diabetes Federation (IDF). IDF DIABETES ATLAS Ninth edition; 2019.
[4] Riskesdas. Hasil Utama Riset Kesehatan Dasar. Kemeterian Kesehatan Republik Indonesia. 2018.
[5] Kusumaningrum, N., and Asriningat, R. Identifikasi Risiko Diabetic Foot Ulcer (DFU) Pada Pasien dengan Diabetes Mellitus. Jurnal Luka Indonesia. 2016; 2(1):56-79.
[6] Andranilla, R. K., and Susilawati, Y. Review of Natural Remedies for Accelerate Diabetic Wound Healing. Journal of Tropical Pharmacy and Chemistry. 2018; 4(3):147-153.
[7] Ferreira, L., Carvalho, A., and Carvalho, R. Short Term Predictors of Amputation in Patient with Diabetic Foot Ulcers. Diabetic and Metabolic syndrome: Clinical Research and Reviews. 2018; 12(6): 875-879.
[8] Khairany, N., Idiawati, N. and Wibowo, M. A. Analisis Sifat Fisik dan Kimia Gel Ekstrak Etanol Daun Talas (Colocasia esculenta). JKK. 2015; 4(2):81-88.
[9] Kementerian Kesehatan Indonesia. Profil Kementerian Kesehatan Indonesia. Kementerian Kesehatan RI; 2017.
[10] Mubayinah and Rahayuningsih. Pengaruh Ekstrak Lompong (Colocasia esculenta) 45 Menit Pengukusan Terhadap Aktivitas Fagositosis dan Kadar NO (Nitrit Oksida) Mencit BALB/C Sebelum dan Sesudah Terinfeks Listeia Monocytogenes. Journal Of Nutrition College. 2015; 2:578-584.
[11] Roxas, L., et al. Efficacy of Tarin from Colocasia esculenta On The Histopatological Changes Of Buffalo Meat (Bubalus bubalis). Journal of Arts, Science and Commerce. 2013; 4(3): 110-116.
[12] Tendean, I. K. Uji Ekstrak Etanol Daun Talas (Colocasia esculenta) Terhadap Gambaran Histopatologi Pankreas Tikus Putih Jantan (Rattus novergicus) Hiperkolesterolemia Diabetes. Farmakologika Jurnal Farmasi. 2017; 14.
[13] Halligudi, N., et al., Pharmacological Potential of Colocasia an Edible Plant. Journal of Drug Discovery and Terapeutics. 2013; 1(2):5-9.
[14] Wijaya, B. A., Citraningtyas, G.and Wehantouw, F. Potensi Ekstrak Etanol Tangkai Daun Talas (Colocasia esculenta) Sebagai Alternatif Obat LukaPada Kulit Kelinci (Oryctolagus cuniculus). Pharmacon. 2014; 3(3).
[15] Ashok, P. and Upadhyaya, K. Tannins are Astrigent. Journal of Pharmacognosy and Phytochemistry. 2012; 1(3): 45-50.
[16] Gemede, H. R. and Hegussie Ratta. Antinutritional Factors in Plant Foods: Potential health Benefits and Adverse Effects. Internatinal Journal Of Nutrition and Food Sciences. 2014; 3: 284-289.
[17] National Center for Biotechnology Information. PubChem Compund Summary for CID 162350, Isovitexin, Orientin, Luteolin, Diosmetin. PubChem. 2020. [cited 2020 Desember]. Available
from:https://pubchem.ncbi.nlm.nih.gov/compound.
[18] Mawarsari, T. Uji Aktivitas Penyembuhan Luka BakarEkstrakEtanol Umbi Talas Jepang (Colocasia esculenta (L.) Schoot var. antiquorum Pada Tikus Putih (Rattus novergicus) Jantan Galur Sprauge Dawley. Thesis. UIN Syarif Hidayatullah Jakarta; 2015.
[19] Cahyaningtyas, Maharani W. Evaluasi Fisika-Kimia dan Penyembuhan Luka Sayat Salep Ekstrak Etanol Tangkai Daun Talas (Colocasia esculenta) Basis Hidrokarbon. Universitas Wahid Haasyim Semarang; 2017.
[20] Muharty, Annisya. Pengaruh Aplikasi Ekstrak Daun Talas (Colocasia esculenta L. Schott) Terhadap Penyembuha Luka Terkontaminasi Bakteri Staphylococcus aureus Melalui Pemeriksaan Neutrofil, Makrofag, Reepitelisasi. Thesis. Fakultas Kedokteran Gigi, Universitas Padjajaran Bandung; 2019.
[21] Marchianti, A. C. N. Gel Formulations Of Merremia Mammosa (Lour.) Accelerated Wound Healing Of The Wound In Diabetic Rats. Journal of Traditional and Complementary Medicine. 2019; doi: 10.1016/j.jtcme. 2019.12.002.
[22] Gomes, A. et al. Wound-healing peptides for treatment of chronic diabetic foot ulcers and other infected skin injuries. Molecules. 2017; 22(10). 1–18.
[23] Sun, X. et al. Maggot debridement therapy promotes diabetic foot wound healing by up-regulating endothelial cell activity. Journal of Diabetes and its Complications. 2016; 30(2): 318–322.
[24] Dhanraj, N. et al. Phytochemical screening and Antibacterial Activity of Western Region wild leaf Colocasia esculenta. International Research Journal of Biological Sciences Int. Res. J. Biological Sci. 2013; 2(10): 2278–3202.
[25] Chakraborty, P. et al. Research Article Cytotoxicity and Antimicrobial Activity of Colocasia esculenta. Journal of Chemical and Pharmaceutical Research. 2015; 7(12): 627-635.
[26] Fadlila, Wildan N., Kiki Mulkiya, Y., Syafnir, L. Identifikasi Senyawa Aktif Antibakteri dengan Metode Bioautografi Klt terhadap Ekstrak Etanol Tangkai Daun Talas (Colocasia esculenta (L.) Schott). Prosiding Penelitian Spesia Unisba. 2015. p. 583–590.
[27] Al Kaf, A. G. et al. Phytochemical Analysis and Antimicrobial Activity of Colocasia esculenta (Taro) Medicinal Plant Leaves Used in Folk Medicine for Treatment of Wounds and Burns in Hufash District Al Mahweet Governorate–Yemen. Universal Journal of Pharmaceutical Research. 2019; 4(2): 29–33.
[28] Singh, B., Namrata and Lokendra Kumar, S. C. D. Antibacterial and Antifungal Activity of Colocasia esculenta Aqueous Extract. Journal of Pharmacy Research. 2011;4(5): 1459–1460.
[29] Umadevi, S., Kumar, S., Mariya. N., Easow, J. M., Kandhakumari, G., Sriangaraj, S., Raj, Sruthi, and Stephen, S. Microbiological Study Of Diabetic Foot Infections. 2011; 2(1): 12–17
[30] Goncalves, R. F. et al. Influence of taro (Colocasia esculenta L. Shott) growth conditions on the phenolic composition and biological properties. Food Chemistry. 2013; 141(4): 3480–3485.
[31] Leong, A. C. N. et al. Flavonoid glycosides in the shoot system of Okinawa Taumu (Colocasia esculenta S.). Food Chemistry. 2010;119(2): 630–635.
[32] Kartika, R. W. et al. Perawatan Luka Kronis dengan Modern Dressing. Perawatan Luka Kronis Dengan Modern Dressing. 2015; 42(7): 546–550.
[33] Marchianti, A. C. N. et al. Gel Formulations Of Merremia Mammosa (Lour.) Accelerated Wound Healing Of The Wound In Diabetic Rats. Journal of Traditional and Complementary Medicine. 2019; doi: 10.1016/j.jtcme. 2019.12.002.
[34] Fujiastuti, T. and Sugihartini, N. Sifat Fisik Dan Daya Iritasi Gel Ekstrak Etanol Herba Pegagan (Centella Asiatica L.) Dengan Variasi Jenis Gelling Agent Physical. Pharmacy. 2015; 12(01): 11–20.
[35] Lai, J. C. Y. et al. Treatment For Diabetic Ulcer Wounds Using A Fern Tannin Optimized Hydrogel Formulation With Antibacterial And Antioxidative Properties. Journal of Ethnopharmacology. 2016; 189: 277–289.
[36] Andarini, Y. N. and Risliawati, A. Variabilitas Karakter Morfologi Plasma Nutfah Talas (Colocasia esculenta) Lokal Pulau Jawa (Morphological Character Variability of Javanese Local Taro [Colocasia esculenta] Germplasm ). Buletin Plasma Nutfah. 2018; 24(1): 63-76.
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2021-05-27
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Ristanti, A. A., Safita, N., Khairunnisa, R., & Ermawati, S. (2021). Efektivitas Gel Ekstrak Tangkai dan Daun Talas (Colocasia esculenta) Terhadap Penyembuhan Luka Diabetes. Prosiding University Research Colloquium, 378–388. Retrieved from https://repository.urecol.org/index.php/proceeding/article/view/1423
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Copyright (c) 2021 Anindya Atiqah Ristanti, Noer Safita, Reza Khairunnisa, Sahilah Ermawati
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